I am Jason Hernandez, a biochemist who lives at the edge between wet lab work and code. Most of my recent time has gone into protein assay development, high-throughput screening, and the work of making data clean enough to trust.

Heat Shock Pineapple is the umbrella I use for my work in science and computation. The name is a nod to the heat shock proteins I studied at UCSF—molecular chaperones that keep other proteins from falling apart when conditions get rough.

I like building experiments starting from the analysis. First comes the question, then a definition of what good signal looks like. After that, I design controls, plate maps, and QC metrics that make that signal obvious.

Biophysics & Wet Lab

  • FP / MST / DSF / TR-FRET
  • Mammalian Cell Culture
  • Protein Purification (His-tag)
  • Organic Synthesis

Automation & Instru.

  • BioTek EL406 / Cytation
  • Beckman Biomek
  • Akta FPLC
  • Agilent HPLC/LC-MS

Computation

  • Python (pandas, scipy)
  • R (tidyverse, ggplot2)
  • PyMOL / AlphaFold / Rosetta
  • SQL / Git / Bash

Postbaccalaureate Research Training (PROPEL)

University of California, San Francisco

NIH-funded excellence program for researchers in biomedical science. Focused on high-throughput screening and neurodegenerative disease mechanisms.

B.S. Biochemistry

San Francisco State University | Minor in Computing Applications

Associates Degrees

Pasadena City College

  • A.S. Engineering and Technology
  • A.S. Natural Sciences

Mentorship & Communication

PROPEL Founding Peer Mentor

University of California, San Francisco

Established the peer mentorship framework for the PROPEL post-baccalaureate program. Developed guidance resources to help incoming scholars navigate lab rotations and experimental design.

PINC Program Peer Mentor

San Francisco State University | 2021–2022

Mentored 8 students in R programming and bioinformatics. Guided team workflows for gene expression and methylation analysis projects.

Supplemental Instructor

San Francisco State University | 2019–2020

Led structured review sessions for Organic Chemistry and Biochemistry. Developed problem-solving materials for metabolic pathway analysis.

Conference Presenter

Presented research findings at ACS National Meeting and The Protein Society.